2. Signaling Pathways
  3. GPCR/G Protein
  4. LPL Receptor

LPL Receptor

Lysophospholipid Receptor

LPL Receptor

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LPL Receptor (Lysophospholipid Receptor) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg". LPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell type is involved, the activated receptor can have a range of effects on the cell. These include primary effects of inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventingapoptosis and increasing cell proliferation. Type: LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, LPAR6, S1PR1, S1PR2, S1PR3, S1PR4, S1PR5.

LPL Receptor Isoform Specific Products:

LPL Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156565A
    S1P1 agonist 6 hemicalcium
    		Agonist
    S1P1 agonist 6 hemicalcium (Compound I) is a S1P1 agonist that reduces autoimmune ability by blocking the transportation of lymphocytes. S1P1 agonist 6 hemicalcium can be used as an immunosuppressive agent in the study of various autoimmune diseases research.
    S1P1 agonist 6 hemicalcium
  • HY-P0103
    Myristoyl pentapeptide-17
    Myristoyl pentapeptide-17 can stimulate eyelash growth by stimulating keratin production. Myristoyl pentapeptide-17 promotes the delivery of key ingredients in the serum, such as the growth factors and lysophosphatidic acid.
    Myristoyl pentapeptide-17
  • HY-139061
    Palmitoyl 3-carbacyclic phosphatidic acid
    Palmitoyl 3-carbacyclic phosphatidic acid (HY-139061) is a palmitoylated Carba-like cyclophosphatidic acid and an analog of lysophosphatidic acid (LPA). Palmitoyl 3-carbacyclic phosphatidic acid has different functions from LPA and can inhibit the activation of RhoA and inhibit the migration of melanoma cells. Palmitoyl 3-carbacyclic phosphatidic acid effectively inhibited experimental lung metastasis and reduced the number of tumor nodules in a B16-F0 xenograft mouse model.
    Palmitoyl 3-carbacyclic phosphatidic acid
  • HY-160823
    2ccPA sodium
    		Inhibitor
    2ccPA sodium is a lysophosphatidic acid (LPA) receptor agonist. 2ccPA sodium modulates processes such as cell proliferation, migration, and apoptosis by activating LPA receptors and inhibiting autotaxin (ATX) enzyme activity. 2ccPA sodium is promising for research of cancers, inflammation, and fibrosis.
    2ccPA sodium
  • HY-120611A
    BMS-960
    		Agonist
    BMS-960 is a potent and selective S1P1 receptor agonist containing isoxazole, which can be used in the research of immune diseases and vascular diseases.
    BMS-960
  • HY-RS12392
    S1pr1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    S1pr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1pr1 Mouse Pre-designed siRNA Set A
  • HY-110314
    CYM50358 hydrochloride
    		Antagonist
    CYM50358 hydrochloride (compound 4v) is a potent, selective sphingosine-1-phosphate 4 (S1P4) receptor antagonist. CYM50358 hydrochloride can be used in the study of influenza infection.
    CYM50358 hydrochloride
  • HY-162996
    Spns2-IN-2
    		Inhibitor
    Spns2-IN-2 (compund 3a) is a SPNS2 inhibitor.
    Spns2-IN-2
  • HY-143864
    S1PR1 agonist 1
    		Agonist
    S1PR1 agonist 1 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 1 has the potential for the research of autoimmune diseases (extracted from patent WO2021175223A1, compound 22).
    S1PR1 agonist 1
  • HY-136577
    RP101442
    		Agonist
    RP101442, an active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 2.6 nM and 171 nM for S1PR1 and S1PR5, respectively.
    RP101442
  • HY-143865
    S1PR1 agonist 2
    		Agonist
    S1PR1 agonist 2 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 2 has the potential for the research of autoimmune diseases (extracted from patent WO2021175225A1, compound 1).
    S1PR1 agonist 2
  • HY-15381S
    Fingolimod phosphate-d4
    Fingolimod phosphate-d4 is deuterium labeled FTY720 Phosphate.
    Fingolimod phosphate-d<sub>4</sub>
  • HY-RS12400
    S1PR4 Human Pre-designed siRNA Set A
    		Inhibitor

    S1PR4 Human Pre-designed siRNA Set A contains three designed siRNAs for S1PR4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1PR4 Human Pre-designed siRNA Set A
  • HY-175201
    pro-FTY
    		Inhibitor
    pro-FTY, a FTY720 (HY-12005) anticancer prodrug, is a sphingosine-1-phosphate (S1P) (HY-108496) inhibitor. pro-FTY specifically inhibits S1P signaling in cancer cells using a drug delivery system (DDS) that reacts with acrolein. pro-FTY significantly inhibits the survival of breast cancer cells, including multidrug-resistant cells and its organoids resistant to Paclitaxel (HY-B0015) or Doxorubicin (HY-15142A). pro-FTY potently suppresses tumor growth in 4T1 cells or organoids xenograft tumors mice model while avoiding lymphocytopenia.
    pro-FTY
  • HY-160661
    LPAR1 antagonist 2
    		Antagonist
    LPAR1 antagonist 2 (example 76) is an LPAR1 antagonist with an average IC50 of 130 nM.
    LPAR1 antagonist 2
  • HY-137862A
    (Rac)-1-Oleoyl lysophosphatidic acid
    		Control
    (Rac)-1-Oleoyl lysophosphatidic acid is an isomer of 1-Oleoyl lysophosphatidic acid sodium (HY-107614). 1-Oleoyl lysophosphatidic acid sodium is a bioactive lipid that can activate the LPA receptors .
    (Rac)-1-Oleoyl lysophosphatidic acid
  • HY-RS12396
    S1pr2 Rat Pre-designed siRNA Set A
    		Inhibitor

    S1pr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for S1pr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1pr2 Rat Pre-designed siRNA Set A
  • HY-171906A
    1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA sodium
    		Inhibitor
    1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) (1-Arachidonoyl-sn-glycerol 3-phosphate (sodium)) is a phospholipid with arachifonic acid at the sn-1 position. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) binds to the LPA2/EDG4 receptor (EC50 of 10 nM). 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can be found in rat brain as 37% of the arachidoinic acid-containing lysophosphatidic acid species. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) is the precursor to 1-arachidonoyl glycerol. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can prevent TNF-α and IL-6 secretion in wild type LPS-stimulated dendritic cells. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) reduces differentiation of HT-29 colon carcinoma cells into goblet cells when sodium butyrate is present.
    1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA sodium
  • HY-171806
    BMT-136088
    		Ligand
    BMT-136088 is a radioligand used for positron emission tomography (PET) imaging of idiopathic pulmonary fibrosis.
    BMT-136088
  • HY-141845
    S1P2 antagonist 1
    		Antagonist
    S1P2 antagonist 1 is an orally bioavailable S1P2 antagonist against fibrotic diseases.
    S1P2 antagonist 1
Cat. No. Product Name / Synonyms Application Reactivity
LPL Receptor Isoform Comparison

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